Epigenetics & DNA methylation
Mapping cytosine methylation and its regulatory roles — from Dnmt1-driven gene silencing in pituitary tumours to non-CG methylation marking the pupa-to-adult transition in the moth Helicoverpa armigera.
Kevin Dudley Lab
We harness long-read sequencing to solve the transcript isoform annotation and quantification problem — understanding life through better genomes.
What we do
From transcriptome assembly to isoform quantification, our work spans the full long-read analysis pipeline.
Mapping cytosine methylation and its regulatory roles — from Dnmt1-driven gene silencing in pituitary tumours to non-CG methylation marking the pupa-to-adult transition in the moth Helicoverpa armigera.
Developing chromatin immunoprecipitation (ChIP) and profiling workflows for non-model organisms, including the first ChIP method for tephritid fruit flies and the histone modifications it revealed.
Building de novo genome and transcriptome resources across diverse species — crustaceans, sea anemones and plants — to enable functional and evolutionary discovery where reference genomes are sparse.
Discovering and characterising thermostable enzymes from Great Artesian Basin microbes, including esterases that degrade plastics — translating extreme-environment biology into biotechnology.
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